With varied implications, Ghana’s temperature and rainfall are projected to rise and decline, respectively. A study exposing specific areas of concern for appropriate responses in this regard is a welcome one. is study sought to describe the temporal variations in temperature and rainfall in the Bawku Area of Ghana. A forty-year (1976–2015) daily climate data was collected on three meteorological stations from the Ghana Meteorological Agency. Normality test, homogeneity test, Standardised Precipitation Index (SPI) analysis, Mann–Kendall trend test, and One-way post hoc ANOVA were performed using XLSTAT and DrinC. Over the period under study, the mean annual rainfall pattern was generally erratic, fluctuating between 669.8mm and 1339.4.6mm with an annual average of 935.3mm. e long-term (40-year period) average temperature of the three stations, on the other hand, was 28.7°C, varying between 26.9°C and 29.9°C annually. Whereas the SPI value of 2006 was ≥2.0, indicating extremely wet year with 2.3% probability of recurring once every 50 years, 1988 was the hottest year with temperature anomaly value of 1.2°C, while coolest years were 1979 (−1.8°C) and 1976 (−1.0°C). e Mann–Kendall trend test showed a rise in rainfall in Binduri, Garu-Tempane, and Manga,yetnoneoftherainfallchanges were statistically significant (P>0.05). Mean temperature on the other handexperiencedasignificantrise (P<0.05). WithanR-square of34.7%,therisein temperaturein Mangawitnessedthe most significant change in annual temperature changes. ere were statistically significant (P<0.05) differences in the interdecadal temperature over the 40-year period. Generally, it can be stated that both temperature and rainfall vary in the study area with various degrees of disparities, but temperature assumes an upward trend at a faster rate. We therefore recommend that stakeholders resort to the construction of dams and boreholes to ensure regular availability of water for both domestic and agricultural uses