The study investigated the determinants of technical efficiency in rice production on the Weta Irrigation Scheme in the Ketu North District of the Volta Region of Ghana during the 2014/2015 cropping season. A two-stage sampling procedure was used to select a sample of 290 rice farmers from a population of 1,024. Primary data, collected from 285 respondents using structured interview schedule, were used for the study. A translog stochastic frontier production function which incorporates a model for inefficiency effects, using the Maximum Likelihood Method was employed in the analysis of the data. Results indicated that the mean technical efficiency index was estimated at 70.7 per cent which implies that the rice farmers were not fully technically efficient. Thus there was the opportunity to increase the output of rice in the study area by 29.3 per cent via efficient reallocation of available resources. Also, the socio-economic characteristics of rice farmers which were significant determinants of technical efficiency in the study area were age, sex, farming experience and membership of a farmer based organization. The study recommended among others that the Ministry of Food and Agriculture should intensify training of farmers on how to improve upon their production activities through the efficient combination of inputs by establishing demonstration farms within the vicinity of farmers. Furthermore, the study recommended the organization of rice farmers in the study area into groups since group membership positively influenced their efficiency.