The study investigates how integrating technology into the healthcare Supply Chain affects operational performance. Using a sample of 212 healthcare facilities in the Accra Metropolitan Area, the study observed that user perceived usefulness and ease-of-use of healthcare supply chain management systems have positive impact on performance. It was also noticed that attitudes of the users of the healthcare supply chain management system do not mediate the linkage between perceived usefulness and healthcare supply chain performance but rather mediate the relationship between perceived ease-of-use and healthcare supply chain performance. As indicated in the United Nations Development Goals 3, the study recommends that structures should be put in place to ensure the use of technology and other related infrastructures, and commitment from both the public and private sectors to ensure the attainment of health and wellbeing for all Ghanaians by the year 2030.