This study investigates the relationships between work-life balance, employee productivity, and organisational commitment among healthcare workers at a leading healthcare facility in the La Nkwantanang Madina Municipality, Ghana. The study adopted a cross-sectional survey design, and the participants comprised 137 employees. Multiple regression approaches, mediation, and moderation analyses were employed to analyse the data. The result so agrees with the hypotheses predicting a positive correlation between work-life balance and productivity (r = 0.48, F <0.001) and organisational commitment (r = 0.55, F<0.001). The mediation analysis results indicated that organisational commitment fully mediates the relationship between work-life balance and productivity (indirect effect β = 0.22, p < 0.001), more specifically, employees with higher levels of organisational commitment amplify the positive effects of work-life balance on productivity. In addition, the main analysis indicated that work-life balance significantly and positively predicted productivity; however, this relationship was moderated by gender, with female workers being more affected by work-life balance than their male counterparts (β = 0.30, p < 0.001). Through the understanding of the results of the study, gender-sensitive work-life balance policies and organisational commitment to increase efficiency are highlighted. As such, future research should further investigate the subsequent changes in work-life balance interventions and other mediators regarding their relations, including job satisfaction and work stress. Limitations include the cross-sectional design, single-site focus, and reliance on self-reported data.