Mathematics plays a vital role in individuals’ ability in dealing with several circles
of life. This study explored the factors affecting students’ performance in Mathematics in
Junior High Schools (JHS) in the Cape Coast Metropolis of Ghana. The descriptive survey
approach was employed for this study. Through random and purposive sampling techniques,
427 JHS 3 pupils were sampled from seven JHS for the study. Questionnaire was used as
the instrument. A simultaneous multiple regression analysis discovered that home factors
had the greatest influence on JHS pupils’ performance in Mathematics. However, personal
factors significantly affected male students performance whiles home factors significantly
affected female students performance in Mathematics. It was recommended that Mathematics
teachers and parents should motivate, encourage and support their children in learning of
Mathematics.