Sports injuries among student-athletes in high schools have become prevalent in most developing countries such as Ghana. In identifying the prevailing injuries among senior high student-athletes in the Akuapem municipality, a descriptive cross-sectional survey design was used. A total of 610 student-athletes were purposely selected for the study to respond to the DEMASS inventory questionnaire regarding their opinion on the prevailing sports injuries. The results indicated that wounds (67.8%), knee injury (65.1%), muscle cramps (56.1%), and thigh injury (55.1%) were prevailing in S.H.S tournament than sprain (37.8%), strain (32.0%), dislocation (30.0%), fracture (31.3%), nose bleeding (31.3%) and groin injuries (23.1%). Participants who played more games professed that the number of games played contributed to sustaining sprain, strain, dislocation, and nose bleeding. Further studies should be carried out at other places and districts to uncover more about injuries sustained during high school sports competitions to minimize their occurrence.