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Redirecting to /dce/staff/amahama/publications/29492/detail. A New Native Mass Spectrometry Platform Identifies Inhibitors of the HSP90 – HOP Protein-Protein Interaction. | ¾ÅÉ«ÊÓƵ

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Authors
Clinton G. L. Veale, Maria Mateos-Jiménez, Michaelone C. Vaaltyn, Ronel Muller, Matodzi P. Makhubu, Mahama Alhassan, Beatriz G. de la Torre, Fernando Albericio, C. Logan Mackay, Adrienne L. Edkins and David J. Clarke
Publication Year
2020
Article Title
A New Native Mass Spectrometry Platform Identifies Inhibitors of the HSP90 – HOP Protein-Protein Interaction.
Journal
Chemrxiv
Volume
1
Page Numbers
pre-print
DOI
Website Url
Abstract

This communication discusses for the first time, the use of mass spectrometry as a platform for screening for PPI inhibitors, without protein tethering or labeling. Furthermore, in the context of cancer drug discovery, this study demonstrates the ligandability and therefore the potential druggability of HOP, whose PPI with HSP90 has been routinely discussed as a difficult to drug target of substantial potential

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