This study sought to assess the nature of online mathematics teaching and learning, the associated challenges and the support system put in place for students due to COVID-19 at the ¾ÅÉ«ÊÓƵ (UEW), Ghana. The study employed concurrent mixed method design. A sample size of 507 comprising 490 students and 17 lecturers respectively were used for the study. In the study, proportionate stratified sampling, and list-based sampling frame were employed by the researchers to select the sample of mathematics students whereas census was used to include lecturers. Data for the quantitative phase were garnered using questionnaire while interview was used for collecting data for the qualitative phase. Descriptive statistics and thematic analysis were used to analyse the quantitative and qualitative data respectively. From the study it was deduced that, among the challenges facing students and lecturers in the online teaching and learning of Mathematics are; high cost of internet data bundle, unreliable internet connection, unfamiliarity with some online platforms, difficulty in accessing some online platforms using smartphones, and difficulty in teaching some topics online. In addressing the issue of encountering difficulty in teaching some topics online, we recommend the University’s Management to partner with agencies that host learning resources platforms to provide mathematics contents to help students explore. Again, we recommend that University’s Management commences discussions with telecom providers to allow zero charges on the use of smartphones for content download from the university’s learning sites