The author examined the experiences of Commercial Sex Workers (CSWs) in Accra, Kumasi, and Kasoa metropolises following Ghana’s imposition of restrictive ACT on 21 March 2020. Three trained male field assistants posing as mystery clients, purposively selected and interviewed 35 CSWs using a combination of face-to-face and telephone interviews with consenting CSWs in the study area. Findings show declined activity and patronage of CSWs due to fear of contracting COVID-19. With no savings or other reliable sources of income, some CSWs have however devised various strategies to work safely and implored the government to support them financially during this crisis.