Despite the fact that online gambling is increasing among students in low- and middle-income countries, studies on the reasons and attitudes of university students toward gambling and its associated social, economic, and academic implications on their lives have not been adequately explored in the Ghanaian setting. This study employed an exploratory research design to investigate the reasons and attitudes of students toward online gambling and how online gambling has affected their social, economic, and academic lives on campus. An interview guide was used in soliciting data from fifteen participants. The thematic analytical framework was used to analyze the data. The analysis of the empirical data revealed that the ease of making quick money, the anonymous nature of online gambling and a source of entertainment were the main reasons why participants engaged in online gambling. Again, concerning participants' attitudes towards gambling, most of them were frequent gamblers and gambled four to seven times a week while a few were occasional gamblers who gambled one to three times a month. The study also found that participants who gambled online ended up becoming depressed, had difficulties with sleeping, and barely concentrated in class because of their addictive attitudes towards online gambling. The study further revealed that the academic lives of participants were negatively affected as a result of excessive gambling. The study recommends that the university management should introduce university gambling policies and programmes to regulate gambling among university students and its associated socio-economic and academic implications.