The study sought to examine the factors that influence users‟ attitudes towards bible application adoption from the Ghanaian perspective. The study used 300 sample size and a purposive technique to solicit views from respondents. Questionnaires were used to elicit information from respondents. Data analysis was performed using SPSS and the SmartPLS application. The study reports that perceived usefulness is not statistically significant in influencing attitudes to learning using bible applications on mobile devices. Contrary to this, perceived ease of use, social influence and application content have a significant influence on the attitude of bible users. The study, therefore, contributes to the research gap on the lack of mobile application studies in developing countries that have emphasized the use of mobile apps. Efforts must be made to conduct the study in different geographical contexts as well as the usage of a mixed method approach to understand the reasons that make people either adopt or reject innovation.